Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

HCV Core Protein antibody (AA 13-124, AA 369-704) (Biotin)

HCV C Reactivity: Hepatitis C Virus (HCV) ELISA, WB, IF, IHC Host: Mouse Monoclonal H6-29 Biotin
Catalog No. ABIN2451996
  • Target See all HCV Core Protein (HCV C) Antibodies
    HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
    Binding Specificity
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 13-124, AA 369-704
    Reactivity
    • 60
    • 5
    • 3
    • 1
    Hepatitis C Virus (HCV)
    Host
    • 45
    • 18
    • 4
    Mouse
    Clonality
    • 45
    • 22
    Monoclonal
    Conjugate
    • 39
    • 9
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HCV Core Protein antibody is conjugated to Biotin
    Application
    • 44
    • 34
    • 16
    • 13
    • 12
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Specificity
    Specific to human HCV core antigen of genotype 1b.
    Cross-Reactivity (Details)
    Not tested in other genotypes.
    Sterility
    Sterile filtered
    Immunogen
    A part of the core region (nucleotides 369-704, aa 13-124) of HCV C expressed in E. coli
    Clone
    H6-29
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product HCV C Primary Antibody
  • Application Notes
    1. Western blotting
    2. Immunohistochemistry
    3. Immunofluorescence staining
    4. ELISA
    Comment

    Conjugate: Bitin conjugated, [biotin] / [IgG] = 6.6

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.7 mg/mL
    Buffer
    PBS, 50 % glycerol
    Preservative
    Azide free
    Storage
    -20 °C
  • Brass, Moradpour, Blum: "Molecular virology of hepatitis C virus (HCV): 2006 update." in: International journal of medical sciences, Vol. 3, Issue 2, pp. 29-34, (2006) (PubMed).

    Manabe, Fuke, Tanishita, Kaji, Gomi, Yoshida, Mori, Takamizawa, Yosida, Okayama: "Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3." in: Virology, Vol. 198, Issue 2, pp. 636-44, (1994) (PubMed).

    Hiramatsu, Hayashi, Haruna, Kasahara, Fusamoto, Mori, Fuke, Okayama, Kamada: "Immunohistochemical detection of hepatitis C virus-infected hepatocytes in chronic liver disease with monoclonal antibodies to core, envelope and NS3 regions of the hepatitis C virus genome." in: Hepatology (Baltimore, Md.), Vol. 16, Issue 2, pp. 306-11, (1992) (PubMed).

    Takamizawa, Mori, Fuke, Manabe, Murakami, Fujita, Onishi, Andoh, Yoshida, Okayama: "Structure and organization of the hepatitis C virus genome isolated from human carriers." in: Journal of virology, Vol. 65, Issue 3, pp. 1105-13, (1991) (PubMed).

    Kato, Hijikata, Ootsuyama, Nakagawa, Ohkoshi, Sugimura, Shimotohno: "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9524-8, (1991) (PubMed).

  • Target
    HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
    Alternative Name
    HCV Core Protein (HCV C Products)
    Target Type
    Viral Protein
    Background
    Hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A, non-B hepatitis. The virus genome consists of a single open reading frame of approximately 9,4 kb which encodes a single polyprotein of about 3,010 amino acids. The polyprotein is processed by host cell and viral proteases into four structural proteins (core, envelope1 and 2, and p7) and six non-structural proteins (NS2, 3, 4a, 4b, 5a, and 5b) necessary for viral replication. HCV core protein is not only a component of nucleocapsid but also has multiple functions and is a pathogenic factor for hepatitis. It also participates in some cellular processes, including transcriptional regulation and cellular transduction. HCV core antigen is used as diagnostic marker for HCV infection.
You are here:
Support