PHOX2A antibody

Catalog No. ABIN2457912

Product Details anti-PHOX2A Antibody

Target: PHOX2A (Paired-Like Homeobox 2a (PHOX2A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHOX2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PHOX2A.

Application Details

Application Notes: PHOX2A antibody can be used for detection of PHOX2A by ELISA at 1:1562500. PHOX2A antibody can be used for detection of PHOX2A by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PHOX2A antibody at -20 °C.

Target Details for PHOX2A

Target: PHOX2A (Paired-Like Homeobox 2a (PHOX2A))

Alternative Name: PHOX2A (PHOX2A Products)

Synonyms: ARIX antibody, CFEOM2 antibody, FEOM2 antibody, NCAM2 antibody, PMX2A antibody, Arix antibody, Phox2 antibody, Pmx2 antibody, Pmx2a antibody, arix antibody, sou antibody, zgc:77364 antibody, phox2 antibody, xphox2a antibody, paired like homeobox 2a antibody, paired-like homeobox 2a antibody, paired like homeobox 2a S homeolog antibody, PHOX2A antibody, Phox2a antibody, phox2a antibody, phox2a.S antibody

Background: PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. PHOX2A has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene.The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 30 kDa

Gene ID: 401

NCBI Accession: NP_005160

UniProt: O14813