RBM5 antibody

Catalog No. ABIN2458330

Product Details anti-RBM5 Antibody

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RBM5.

Application Details

Application Notes: RBM5 antibody can be used for detection of RBM5 by ELISA at 1:312500. RBM5 antibody can be used for detection of RBM5 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store RBM5 antibody at -20 °C.

Target Details for RBM5

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Alternative Name: RBM5 (RBM5 Products)

Synonyms: wu:fc25a08 antibody, wu:fe06f12 antibody, g15 antibody, h37 antibody, luca15 antibody, rbm5 antibody, rmb5 antibody, RBM5 antibody, G15 antibody, LUCA15 antibody, RMB5 antibody, D030069N10Rik antibody, RNA binding motif protein 5 antibody, RNA binding motif protein 5 S homeolog antibody, RNA binding motif protein 5 L homeolog antibody, rbm5 antibody, rbm5.S antibody, RBM5 antibody, rbm5.L antibody, Rbm5 antibody

Background: RBM5 is a component of the spliceosome A complex.It regulates alternative splicing of a number of mRNAs. RBM5 may modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. RBM5 may both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, RBM5 promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

Molecular Weight: 92 kDa

Gene ID: 10181

NCBI Accession: NP_005769

UniProt: P52756

Pathways: Ribonucleoprotein Complex Subunit Organization