CELF6 antibody

Catalog No. ABIN2458550

Product Details anti-CELF6 Antibody

Target: CELF6 (CUGBP, Elav-Like Family Member 6 (CELF6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CELF6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BRUNOL6.

Application Details

Application Notes: BRUNOL6 antibody can be used for detection of BRUNOL6 by ELISA at 1:62500. BRUNOL6 antibody can be used for detection of BRUNOL6 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store BRUNOL6 antibody at -20 °C.

Target Details for CELF6

Target: CELF6 (CUGBP, Elav-Like Family Member 6 (CELF6))

Alternative Name: BRUNOL6 (CELF6 Products)

Synonyms: BRUNOL6 antibody, 6330569O16Rik antibody, Brunol6 antibody, CUGBP Elav-like family member 6 antibody, CUGBP, Elav-like family member 6 antibody, CELF6 antibody, Celf6 antibody

Background: BRUNOL6 is a RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. It mediates exon inclusion and/or exclusion in pre-mRNAs that are subject to tissue-specific and developmentally regulated alternative splicing. BRUNOL6 specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. It also promotes exon exclusion of INSR pre-mRNA.Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation.

Molecular Weight: 50 kDa

Gene ID: 60677

NCBI Accession: NP_443072

UniProt: Q96J87