Desmocollin 3 antibody

Catalog No. ABIN2458921

Product Details anti-Desmocollin 3 Antibody

Target: Desmocollin 3 (DSC3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DSC3.

Application Details

Application Notes: DSC3 antibody can be used for detection of DSC3 by ELISA at 1:62500. DSC3 antibody can be used for detection of DSC3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store DSC3 antibody at -20 °C.

Target Details for Desmocollin 3

Target: Desmocollin 3 (DSC3)

Alternative Name: DSC3 (DSC3 Products)

Synonyms: CDHF3 antibody, DSC antibody, DSC1 antibody, DSC2 antibody, DSC4 antibody, HT-CP antibody, 5430426I24Rik antibody, MGC85083 antibody, desmocollin 3 antibody, desmocollin 3 S homeolog antibody, DSC3 antibody, Dsc3 antibody, dsc3.S antibody, dsc3 antibody

Background: DSC3 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.

Molecular Weight: 85 kDa

Gene ID: 1825

NCBI Accession: NP_001932

UniProt: Q14574