LOXL1 antibody

Catalog No. ABIN2459810

Product Details anti-LOXL1 Antibody

Target: LOXL1 (Lysyl Oxidase-Like 1 (LOXL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LOXL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LOXL1.

Application Details

Application Notes: LOXL1 antibody can be used for detection of LOXL1 by ELISA at 1:312500. LOXL1 antibody can be used for detection of LOXL1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store LOXL1 antibody at -20 °C.

Target Details for LOXL1

Target: LOXL1 (Lysyl Oxidase-Like 1 (LOXL1))

Alternative Name: LOXL1 (LOXL1 Products)

Synonyms: LOL antibody, LOXL antibody, Loxl antibody, si:ch211-238c15.1 antibody, lol antibody, loxl antibody, loxl-1 antibody, oxl-1 antibody, lysyl oxidase like 1 antibody, lysyl oxidase-like 1 antibody, lysyl oxidase like 1 L homeolog antibody, LOXL1 antibody, loxl1 antibody, Loxl1 antibody, loxl1.L antibody

Background: LOXL1 is a member of the lysyl oxidase family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 53 kDa

Gene ID: 4016

NCBI Accession: NP_005567

UniProt: Q08397