Cyclin T1 antibody

Catalog No. ABIN2460095

Product Details anti-Cyclin T1 Antibody

Target: Cyclin T1 (CCNT1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin T1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CCNT1.

Application Details

Application Notes: CCNT1 antibody can be used for detection of CCNT1 by ELISA at 1:1562500. CCNT1 antibody can be used for detection of CCNT1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store CCNT1 antibody at -20 °C.

Target Details for Cyclin T1

Target: Cyclin T1 (CCNT1)

Alternative Name: CCNT1 (CCNT1 Products)

Synonyms: CG6292 antibody, Dmcyclin T antibody, Dmel\\CG6292 antibody, ORE-14 antibody, P-TEFb antibody, anon-74EFc antibody, dT antibody, p124 antibody, Cyclin-T1 antibody, ccnt antibody, cyct1 antibody, CCNT antibody, CYCT1 antibody, HIVE1 antibody, 2810478G24Rik antibody, AI115585 antibody, CycT1 antibody, fi75b02 antibody, si:dkey-18f23.10 antibody, wu:fi75b02 antibody, Cyclin T antibody, cyclin T1 antibody, cyclin T1 L homeolog antibody, CycT antibody, CCNT1 antibody, ccnt1 antibody, Ccnt1 antibody, ccnt1.L antibody

Background: CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 81 kDa

Gene ID: 904

NCBI Accession: NP_001231

UniProt: O60563