Junctophilin 2 antibody

Catalog No. ABIN2463428

Product Details anti-Junctophilin 2 Antibody

Target: Junctophilin 2 (JPH2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Junctophilin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human JPH2.

Application Details

Application Notes: JPH2 antibody can be used for detection of JPH2 by ELISA at 1:312500. JPH2 antibody can be used for detection of JPH2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store JPH2 antibody at -20 °C.

Target Details for Junctophilin 2

Target: Junctophilin 2 (JPH2)

Alternative Name: JPH2 (JPH2 Products)

Synonyms: CMH17 antibody, JP-2 antibody, JP2 antibody, jp antibody, 1110002E14Rik antibody, Jp2 antibody, junctophilin 2 antibody, junctophilin-2 antibody, JPH2 antibody, LOC100461095 antibody, LOC610874 antibody, Jph2 antibody

Background: Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. JPH2 is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.

Molecular Weight: 74 kDa

Gene ID: 57158

NCBI Accession: NP_065166

UniProt: Q9BR39