PADI2 antibody

Catalog No. ABIN2463506

Product Details anti-PADI2 Antibody

Target: PADI2 (Peptidyl Arginine Deiminase, Type II (PADI2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PADI2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PADI2.

Application Details

Application Notes: PADI2 antibody can be used for detection of PADI2 by ELISA at 1:12500. PADI2 antibody can be used for detection of PADI2 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PADI2 antibody at -20 °C.

Target Details for PADI2

Target: PADI2 (Peptidyl Arginine Deiminase, Type II (PADI2))

Alternative Name: PADI2 (PADI2 Products)

Synonyms: PADI2 antibody, PAD-H19 antibody, PAD2 antibody, PDI2 antibody, Pdi antibody, Pdi2 antibody, mKIAA0994 antibody, peptidyl arginine deiminase 2 antibody, peptidyl arginine deiminase, type II antibody, protein-arginine deiminase type-2 antibody, peptidyl arginine deiminase, type II S homeolog antibody, PADI2 antibody, padi2 antibody, LOC100357368 antibody, padi2.S antibody, Padi2 antibody

Background: PADI2 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. PADI2 is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis.This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 75 kDa

Gene ID: 11240

NCBI Accession: NP_031391

UniProt: Q9Y2J8