HSD11B2 antibody (AA 181-405)

Catalog No. ABIN2468177

Product Details anti-HSD11B2 Antibody

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Binding Specificity: AA 181-405

Reactivity: Human, Rat, Chicken

Host: Chicken

Clonality: Polyclonal

Conjugate: This HSD11B2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Immunoaffinity Purified

Application Details

Application Notes: Corticosteroid 11-beta-dehydrogenase, isozyme 2 antibody can be used for the detection of Corticosteroid 11-beta-dehydrogenase, isozyme 2 by Western Blot.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: HSD11B2 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Target Details for HSD11B2

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Alternative Name: HSD11B2 (HSD11B2 Products)

Synonyms: MGC81883 antibody, 11-HSD2 antibody, AME antibody, AME1 antibody, HSD11K antibody, HSD2 antibody, SDR9C3 antibody, 11HSD2 antibody, HSD11B2 antibody, hydroxysteroid (11-beta) dehydrogenase 2 L homeolog antibody, hydroxysteroid 11-beta dehydrogenase 2 antibody, hsd11b2.L antibody, HSD11B2 antibody, Hsd11b2 antibody

Background: FUNCTION: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

DISEASE: Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.

Molecular Weight: 44.1 kDa (calculated)

Gene ID: 3291

NCBI Accession: NP_000187

UniProt: P80365

Pathways: Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones