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TACI antibody (AA 116-132)

TNFRSF13B Reactivity: Human, Mouse WB, FACS, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2470171
  • Target See all TACI (TNFRSF13B) Antibodies
    TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))
    Binding Specificity
    • 16
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 116-132
    Reactivity
    • 31
    • 26
    • 7
    • 2
    • 2
    • 2
    • 2
    Human, Mouse
    Host
    • 32
    • 10
    • 10
    • 3
    Rabbit
    Clonality
    • 34
    • 21
    Polyclonal
    Conjugate
    • 30
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TACI antibody is un-conjugated
    Application
    • 40
    • 18
    • 16
    • 14
    • 14
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
    Purification
    Protein G Column
    Immunogen
    TNFRSF13B antibody was raised against amino acids 116 - 132 of TNFRSF13B (Human).
    Isotype
    IgG
    Top Product
    Discover our top product TNFRSF13B Primary Antibody
  • Application Notes
    TNFRSF13B antibody can be used in Western Blot starting at 1:1000, immunohistochemistry starting at 5 μg/mL, immunohistochemistry -Pfa starting at 1 μg/mL, and flow cytometry.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS containing 0.05 % sodium azide and 0.2 % gelatin.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    As with all antibodies avoid freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    TNFRSF13B antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.
  • Target
    TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))
    Alternative Name
    TNFRSF13B (TNFRSF13B Products)
    Synonyms
    CD267 antibody, CVID antibody, CVID2 antibody, RYZN antibody, TACI antibody, TNFRSF14B antibody, TNFRSF13B antibody, 1200009E08Rik antibody, Taci antibody, TNF receptor superfamily member 13B antibody, tumor necrosis factor receptor superfamily, member 13b antibody, TNFRSF13B antibody, Tnfrsf13b antibody
    Background
    Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 , THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase , BAFF (for B cell activating factor belonging to the TNF family) and BlyS (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells. Recently two orphan receptors TACI and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-κ,B, and AP-1. TACI is one of three know receptors for BLys. Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-κ,B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
    Gene ID
    23495
    UniProt
    O14836
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