FYN antibody (FYN Oncogene Related To SRC, FGR, YES) (AA 7-176)

Details for Product anti-FYN Antibody No. ABIN2473714, Supplier: Log in to see
Antigen
  • im:6908851
  • si:dkey-119m7.5
  • zgc:109996
  • c-fyn
  • cfyn-a
  • SLK
  • SYN
  • p59-FYN
  • PKC
  • fyn
  • zgc:86720
  • AI448320
  • AW552119
  • FYN proto-oncogene, Src family tyrosine kinase
  • FYN proto-oncogene, Src family tyrosine kinase S homeolog
  • FYN proto-oncogene, Src family tyrosine kinase b
  • FYN proto-oncogene, Src family tyrosine kinase L homeolog
  • FYN proto-oncogene, Src family tyrosine kinase a
  • Fyn proto-oncogene
  • FYN
  • fyn.S
  • fynb
  • fyn.L
  • Fyn
  • fyna
Alternatives
anti-Human FYN antibody for Immunocytochemistry
Epitope
AA 7-176
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Reactivity
Human, Mouse (Murine)
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This FYN antibody is un-conjugated
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Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen Bacterially expressed recombinant fragment of human fyn aa 7-176.
Clone FYN-01
Isotype IgG2b
Specificity This antibody recognizes p59fyn (fyn), a 59 kDa member of the src family of non receptor protein tyrosine kinases, expressed by T cells and Natural Killer (NK) cells and highly expressed in brain. Fyn plays a vital role in thymocyte development and T cell activation and is essential for TCR-mediated signal transduction through association with the T Cell Receptor (TCR) eta chain/CD3 Complex. This association, results in protein kinase activation and the subsequent protein tyrosine phosphorylation of multiple immunoreceptor tyrosine-based activation motifs (ITAMs), which triggers the phosphorylation of further substrates downstream in the T cell signaling cascade. Recent studies into Alzheimer's Disease have implicated fyn in neurodegeneration, through the tyrosine phosphorylation of the microtubule-associated protein tau, a prominent component of neurofibrillary tangles.
Cross-Reactivity Mouse (Murine)
Characteristics Purified IgG
Purification Purified
Plasmids, Primers & others Plasmids, Primers & others FYN products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name FYN (FYN Antibody Abstract)
Gene ID 2534
UniProt P06241
Pathways JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Product cited in: Meraner, Horejsí, Wolpl, Fischer, Stingl, Maurer: "Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 4, pp. 2262-71, 2007 (PubMed).

Ho, Hashimoto, Adame, Izu, Alford, Thal, Hansen, Masliah: "Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role." in: Neurobiology of aging, Vol. 26, Issue 5, pp. 625-35, 2005 (PubMed).

Lee, Thangavel, Sharma, Litersky, Bhaskar, Fang, Do, Andreadis, Van Hoesen, Ksiezak-Reding: "Phosphorylation of tau by fyn: implications for Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 9, pp. 2304-12, 2004 (PubMed).

Background publications Borok, Farina, Leider: "Radiotherapy for Kaposi's sarcoma." in: The Journal of dermatologic surgery and oncology, Vol. 5, Issue 1, pp. 39-42, 1979 (PubMed).

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