NFKBIA antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha) (C-Term)

Details for Product anti-NFKBIA Antibody No. ABIN2475865
Antigen
  • IKBA
  • MAD-3
  • NFKBI
  • AI462015
  • Nfkbi
  • RL/IF-1
  • ECI-6/IKBA
  • ikbaA
  • wu:fj16a07
  • zgc:85769
  • NFKB inhibitor alpha
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
  • NFKBIA
  • Nfkbia
  • nfkbiaa
Epitope
C-Term
63
55
40
35
35
17
17
15
15
12
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10
8
7
7
5
5
4
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4
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3
3
3
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2
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2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
485
307
247
31
24
20
19
9
2
2
2
1
1
Host
Rabbit
429
62
7
7
Clonality
Polyclonal
Conjugate
This NFKBIA antibody is un-conjugated
26
13
13
13
13
13
13
12
10
6
6
6
3
3
3
3
3
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), ELISA, Western Blotting (WB)
363
181
159
78
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61
41
28
19
17
16
4
4
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2
1
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1
Options
Immunogen NFkBIa peptide corresponding to a region near the C-terminus of the human protein, conjugated with KLH.
Isotype IgG
Specificity This antibody is specific for NF-kappa-B inhibitor alpha (also known as IkB alpha), one of seven members of the IkB class of inhibitor proteins that have been identified to date. NFkBIa inhibits the NFkB complex in unstimulated cells through non-covalent binding. Following stimulation of cells, IkB alpha is phosphorylated so that it dissociates from the NFkB, and then ubiquinated prior to degradation.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics Serum
Plasmids, Primers & others Plasmids, Primers & others NFKBIA products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name NF kappa B INHIBITOR alpha (NFKBIA Antibody Abstract)
Background Synonyms: IkB ALPHA
Gene ID 4792
UniProt P25963
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 80.0 mg/mL
Product cited in: Hoffmann, Levchenko, Scott, Baltimore: "The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation." in: Science (New York, N.Y.), Vol. 298, Issue 5596, pp. 1241-5, 2002 (PubMed).

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