Presenilin 1 antibody (PSEN1) (Loop)

Details for Product anti-PSEN1 Antibody No. ABIN2476201
Antigen
  • pre1
  • psen
  • zfPS1
  • zf-PS1
  • ad3
  • fad
  • ps1
  • s182
  • X-PS-beta
  • X-PS-alpha
  • AD3
  • FAD
  • PS-1
  • PS1
  • S182
  • Ad3h
  • presenilin 1
  • presenilin 1 L homeolog
  • psen1
  • PSEN1
  • Psen1
  • psen1.L
Epitope
Loop
36
34
24
24
13
9
9
7
6
6
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Monkey
282
144
127
32
13
9
8
6
4
3
3
2
1
1
1
Host
Rabbit
223
41
16
4
3
2
Clonality
Polyclonal
Conjugate
This Presenilin 1 antibody is un-conjugated
15
11
9
7
7
7
7
7
7
5
5
5
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
210
136
106
40
39
24
12
11
6
5
5
3
2
1
Options
Isotype IgG
Specificity This antibody recognises presenilin-1 (PSEN1), an integral membrane protein that is widely expressed, especially in brain tissue.PSEN1 is an essential component of the gamma-secretase complex, along with APH-1 (APH-1A or APH-1B), PSEN2, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes. . Mutations of presenilin-1 are associated with early onset Alzheimer's disease.
Cross-Reactivity Monkey
Characteristics Serum
Plasmids, Primers & others Plasmids, Primers & others Presenilin 1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PRESENILIN-1 (PSEN1 Antibody Abstract)
Background Synonyms: PSEN1
Gene ID 5663
UniProt P49768
Pathways Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
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