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DLG3 antibody (Discs, Large Homolog 3 (Drosophila)) (AA 1-120) (APC) Primary Antibody

DLG3 Reactivity: Human, Mouse, Rat AA, ICC, IF, IHC, IP, WB Host: Mouse Monoclonal S19-2 APC
Catalog No. ABIN2482569
$455.00
Plus shipping costs $45.00
100 μg
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  • Target
    DLG3
    Binding Specificity
    AA 1-120
    • 10
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human, Mouse, Rat
    • 38
    • 38
    • 35
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Host
    Mouse
    Clonality
    Monoclonal
    Conjugate
    This DLG3 antibody is conjugated to APC
    • 27
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Antibody Array (AA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
    • 37
    • 17
    • 16
    • 13
    • 11
    • 10
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Specificity
    Detects ~105 kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1-120 of rat SAP102
    Clone
    S19-2
    Isotype
    IgG1
  • Application Notes
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml was sufficient for detection of Sap102 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    DLG3
    Alternative Name
    SAP102 (DLG3 Antibody Abstract)
    Synonyms
    MRX, MRX90, NEDLG, SAP102, XLMR, fa66c08, fa66e02, fd02c12, fu95c12, im:7138640, si:ch211-276g21.1, wu:fa66c08, wu:fa66e02, wu:fd02c12, wu:fu95c12, Dlgh3, mKIAA1232, MPP3, discs large MAGUK scaffold protein 3, discs, large homolog 3 (Drosophila), DLG3, dlg3, Dlg3
    Background
    Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
    Gene ID
    58948
    NCBI Accession
    NP_113827
    UniProt
    Q62936
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