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ABCC8 antibody (AA 1548-1582) (PE)

ABCC8 Reactivity: Rat WB, IHC, ICC, IF Host: Mouse Monoclonal S289-16 PE
Catalog No. ABIN2483000
  • Target See all ABCC8 Antibodies
    ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
    Binding Specificity
    • 11
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1548-1582
    Reactivity
    • 30
    • 20
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 24
    • 19
    • 1
    Mouse
    Clonality
    • 26
    • 18
    Monoclonal
    Conjugate
    • 22
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ABCC8 antibody is conjugated to PE
    Application
    • 30
    • 20
    • 15
    • 13
    • 11
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    Detects ~160 kDa. Does not cross-react with SUR2B.
    Cross-Reactivity
    Hamster, Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
    Clone
    S289-16
    Isotype
    IgG1
    Top Product
    Discover our top product ABCC8 Primary Antibody
  • Application Notes
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN2483000 was sufficient for detection of SUR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
    Alternative Name
    SUR1 (ABCC8 Products)
    Synonyms
    ABC36 antibody, HHF1 antibody, HI antibody, HRINS antibody, MRP8 antibody, PHHI antibody, SUR antibody, SUR1 antibody, SUR1delta2 antibody, TNDM2 antibody, D930031B21Rik antibody, Sur antibody, Sur1 antibody, ATP binding cassette subfamily C member 8 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 8 antibody, ABCC8 antibody, Abcc8 antibody
    Background
    Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).
    Gene ID
    25559
    NCBI Accession
    NP_037171
    UniProt
    Q09429
    Pathways
    Negative Regulation of Hormone Secretion
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