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Nav1.8 antibody (AA 1724-1956) (Biotin)

SCN10A Reactivity: Rat IHC, WB, IF, ICC, AA Host: Mouse Monoclonal S134 Biotin
Catalog No. ABIN2483063
  • Target See all Nav1.8 (SCN10A) Antibodies
    Nav1.8 (SCN10A) (Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A))
    Binding Specificity
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1724-1956
    Reactivity
    • 18
    • 16
    • 3
    • 1
    Rat
    Host
    • 17
    • 14
    • 1
    • 1
    Mouse
    Clonality
    • 19
    • 14
    Monoclonal
    Conjugate
    • 13
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Nav1.8 antibody is conjugated to Biotin
    Application
    • 19
    • 19
    • 15
    • 12
    • 10
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    Specificity
    Detects ~220 kDa. No cross reactivity against other Nav channels.
    Cross-Reactivity
    Human, Monkey, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1724-1956 of rat Nav1.8
    Clone
    S134
    Isotype
    IgG2a
    Top Product
    Discover our top product SCN10A Primary Antibody
  • Application Notes
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN2483063 was sufficient for detection of Nav1.8 in 10 μg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    Nav1.8 (SCN10A) (Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A))
    Alternative Name
    Nav1.8 (SCN10A Products)
    Synonyms
    Nav1.8 antibody, PN3 antibody, SNS antibody, hPN3 antibody, Na(V)1.8 antibody, sodium channel, voltage-gated, type X, alpha antibody, sodium voltage-gated channel alpha subunit 10 antibody, Scn10a antibody, SCN10A antibody
    Background
    Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.
    Gene ID
    29571
    NCBI Accession
    NP_058943
    UniProt
    Q62968
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