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SCN9A antibody (AA 1751-1946) (PerCP)

SCN9A Reactivity: Human IHC, WB, IF, IP, ICC, AA Host: Mouse Monoclonal N68-6 (Formerly S68-6) PerCP
Catalog No. ABIN2483101
  • Target See all SCN9A Antibodies
    SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))
    Binding Specificity
    • 11
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1751-1946
    Reactivity
    • 41
    • 14
    • 10
    • 1
    • 1
    • 1
    Human
    Host
    • 25
    • 17
    • 1
    • 1
    Mouse
    Clonality
    • 27
    • 17
    Monoclonal
    Conjugate
    • 23
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SCN9A antibody is conjugated to PerCP
    Application
    • 25
    • 22
    • 14
    • 12
    • 12
    • 12
    • 10
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)
    Specificity
    Detects ~230 kDa. No cross-reactivity against other Nav channels.
    Cross-Reactivity
    Hamster, Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
    Clone
    N68-6 (Formerly S68-6)
    Isotype
    IgG1
    Top Product
    Discover our top product SCN9A Primary Antibody
  • Application Notes
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN2483101 was sufficient for detection of Nav1.7 in 10 μg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))
    Alternative Name
    Nav1.7 (SCN9A Products)
    Synonyms
    SCN9A antibody, DKFZp459G084 antibody, Nav1.7 antibody, PN1 antibody, mKIAA4197 antibody, Scn2a antibody, ETHA antibody, FEB3B antibody, GEFSP7 antibody, NE-NA antibody, NENA antibody, SFNP antibody, sodium channel, voltage-gated, type IX, alpha subunit antibody, sodium voltage-gated channel alpha subunit 9 antibody, sodium channel protein type 9 subunit alpha antibody, sodium channel, voltage-gated, type IX, alpha antibody, SCN9A antibody, LOC100016648 antibody, Scn9a antibody
    Background
    Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).
    Gene ID
    6335
    NCBI Accession
    NP_002968
    UniProt
    Q15858
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