TRPC7 antibody (AA 845-862) (Atto 488)

Catalog No. ABIN2485420

Product Details anti-TRPC7 Antibody (Atto 488)

Target: TRPC7 (Transient Receptor Potential Cation Channel, Subfamily C, Member 7 (TRPC7))

Binding Specificity: AA 845-862

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TRPC7 antibody is conjugated to Atto 488

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)

Specificity: Detects ~100 kDa.

Cross-Reactivity: Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Synthetic peptide amino acids 845-862 of human TRPC7

Clone: N64A-36 (Formerly S64A-36)

Isotype: IgG1

Application Details

Application Notes:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN2485420 was sufficient for detection of TrpC7 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Conjugated antibodies should be stored at 4°C

Target Details for TRPC7

Target: TRPC7 (Transient Receptor Potential Cation Channel, Subfamily C, Member 7 (TRPC7))

Alternative Name: TRPC7 (TRPC7 Products)

Synonyms: TRP7 antibody, TRP-7 antibody, Trrp8 antibody, TRPC7 antibody, TRPM2 antibody, transient receptor potential cation channel subfamily C member 7 antibody, transient receptor potential cation channel, subfamily C, member 7 antibody, short transient receptor potential channel 7 antibody, TRPC7 antibody, Trpc7 antibody, LOC100012798 antibody

Background: Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a non-selective cation channel that is directly activated by DAG. TrpC7 shows constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Because of this, TrpC7 plays an important role in the Ca2+ signaling pathway (1). TrpC7 is also expressed abundantly in the heart, and combined with its ability to act as a Ca2+ channel, TrpC7 might contribute to the process of heart failure (2).

Gene ID: 57113

NCBI Accession: NP_065122

UniProt: Q9HCX4