KCNJ8 antibody (AA 306-424) (Alkaline Phosphatase (AP))

Catalog No. ABIN2485708

Product Details anti-KCNJ8 Antibody (Alkaline Phosphatase (AP))

Target: KCNJ8 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8))

Binding Specificity: AA 306-424

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNJ8 antibody is conjugated to Alkaline Phosphatase (AP)

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Detects ~45 kDa.

Cross-Reactivity: Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1

Clone: S366-60

Isotype: IgG2a

Application Details

Application Notes:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Comment:

A 1:100 dilution of ABIN2485708 was sufficient for detection of Kir6.1 in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Conjugated antibodies should be stored at 4°C

Target Details for KCNJ8

Target: KCNJ8 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8))

Alternative Name: Kir6.1 (KCNJ8 Products)

Synonyms: kir6.1 antibody, KIR6.1 antibody, uKATP-1 antibody, AI448900 antibody, Kir6.1 antibody, gnite antibody, slmbr antibody, sltr antibody, UKATP1 antibody, si:dkey-183c2.2 antibody, zkir6.1 antibody, potassium voltage-gated channel subfamily J member 8 antibody, potassium channel, inwardly rectifying subfamily J, member 8 antibody, potassium inwardly-rectifying channel, subfamily J, member 8 antibody, potassium channel, inwardly rectifying subfamily J, member 8 S homeolog antibody, KCNJ8 antibody, kcnj8 antibody, Kcnj8 antibody, kcnj8.S antibody

Background: Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).

Gene ID: 25472

NCBI Accession: NP_058795

UniProt: Q63664