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BIM antibody (Alkaline Phosphatase (AP))

BCL2L11 Reactivity: Human WB, IHC Host: Rabbit Polyclonal Alkaline Phosphatase (AP)
Catalog No. ABIN2485935
  • Target See all BIM (BCL2L11) Antibodies
    BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
    Reactivity
    • 178
    • 101
    • 91
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 166
    • 9
    • 5
    • 1
    Rabbit
    Clonality
    • 151
    • 30
    Polyclonal
    Conjugate
    • 69
    • 16
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BIM antibody is conjugated to Alkaline Phosphatase (AP)
    Application
    • 123
    • 64
    • 51
    • 28
    • 25
    • 22
    • 15
    • 14
    • 14
    • 13
    • 10
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    Detects ~23 kDa.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein A Purified
    Immunogen
    Internal central amino acids of human Bim
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    Discover our top product BCL2L11 Primary Antibody
  • Application Notes
    • WB (1:1000)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN2485935 was sufficient for detection of Bim in 20 μg of K562 and A549 cell lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
    Alternative Name
    BIM/BOD (BCL2L11 Products)
    Synonyms
    bim antibody, BAM antibody, BIM antibody, BOD antibody, 1500006F24Rik antibody, Bim antibody, Bod antibody, BimL antibody, BIMEL antibody, BCL2-like 11 antibody, BCL2 like 11 antibody, BCL2-like 11 (apoptosis facilitator) antibody, bcl2l11 antibody, BCL2L11 antibody, Bcl2l11 antibody
    Background
    Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1 ,2).
    Gene ID
    10018
    NCBI Accession
    NP_619527
    UniProt
    O43521
    Pathways
    PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
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