COMP antibody (AA 221-320) (HRP)

Catalog No. ABIN2559646

Product Details anti-COMP Antibody (HRP)

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Binding Specificity: AA 221-320

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMP antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COMP

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for COMP

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Alternative Name: COMP (COMP Products)

Synonyms: COMP antibody, EDM1 antibody, EPD1 antibody, MED antibody, PSACH antibody, THBS5 antibody, TSP5 antibody, cartilage oligomeric matrix protein antibody, COMP antibody, sce3551 antibody, CJA_1292 antibody, Comp antibody

Background:

Synonyms: MED, EDM1, EPD1, PSACH, THBS5, Cartilage oligomeric matrix protein, COMP, Thrombospondin-5, TSP5

Background: May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).

Gene ID: 1311

UniProt: P49747