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CILP antibody (AA 1051-1184)

CILP Reactivity: Human, Rat WB, ELISA, FACS, ICC, IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2559699
  • Target See all CILP Antibodies
    CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
    Binding Specificity
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1051-1184
    Reactivity
    • 25
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 19
    • 4
    • 2
    • 2
    Rabbit
    Clonality
    • 24
    • 3
    Polyclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CILP antibody is un-conjugated
    Application
    • 24
    • 13
    • 12
    • 12
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    The immunogen falls within the Cartilage intermediate layer protein 1 C2 region.
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CILP
    Isotype
    IgG
    Top Product
    Discover our top product CILP Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
    Alternative Name
    CILP (CILP Products)
    Synonyms
    CILP-1 antibody, HsT18872 antibody, 9830114D16 antibody, C130036G17Rik antibody, NTPPH antibody, CILP antibody, im:7137994 antibody, cartilage intermediate layer protein antibody, cartilage intermediate layer protein, nucleotide pyrophosphohydrolase antibody, cartilage intermediate layer protein 1 antibody, CILP antibody, Cilp antibody, cilp antibody, LOC100336614 antibody
    Background

    Synonyms: CILP-1, HsT18872, Cartilage intermediate layer protein 1, Cartilage intermediate-layer protein, CILP, UNQ602/PRO1188

    Background: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

    Gene ID
    8483
    UniProt
    O75339
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