TIGIT antibody (PE)

Catalog No. ABIN2568497

Product Details anti-TIGIT Antibody (PE)

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIGIT antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: The 1G9 monoclonal antibody specifically binds to the mouse TIGIT, expressed on the T helper cells.

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Clone: 1G9

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Storage: 4 °C

Storage Comment: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.

Target Details for TIGIT

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Alternative Name: TIGIT (TIGIT Products)

Synonyms: VSIG9 antibody, VSTM3 antibody, WUCAM antibody, ENSMUSG00000071552 antibody, Vstm3 antibody, RGD1563191 antibody, T-cell immunoreceptor with Ig and ITIM domains antibody, T cell immunoreceptor with Ig and ITIM domains antibody, TIGIT antibody, Tigit antibody

Background: The 1G9 monoclonal antibody specifically binds to the mouse TIGIT, expressed on the T helper cells. While in humans it is expressed also on natural killer cells, Treg cells, memory CD4+ and CD8+ T lymphocytes. TIGIT is not expressed on B cells and is upregulated on CD4+ T cells following activation.TIGIT interacts with CD155, and mediates the interaction between natural killer cells or T lymphocytes with APC and fibroblasts and endothelial cells expressing PVR or PVR-like proteins.

Gene ID: 100043314

UniProt: P86176

Pathways: Cancer Immune Checkpoints