PPAP2A antibody

Catalog No. ABIN265043

Product Details anti-PPAP2A Antibody

Target: PPAP2A (Phosphatidic Acid Phosphatase Type 2A (PPAP2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPAP2A antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody recognizes Lysophospholipid Phosphatase (LPP) 1/1A.

Purification: Purified

Immunogen: Synthetic peptide derived from the LPP1 protein.

Isotype: IgG

Application Details

Application Notes: Western Blot: 5-10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C.

Target Details for PPAP2A

Target: PPAP2A (Phosphatidic Acid Phosphatase Type 2A (PPAP2A))

Alternative Name: PPAP2A / LPP1 (PPAP2A Products)

Synonyms: PPAP2A antibody, wun antibody, LLP1a antibody, LPP1 antibody, PAP-2a antibody, PAP2 antibody, Hic53 antibody, Hpic53 antibody, LPP-1 antibody, mPAP antibody, PAP2A antibody, PAP2a2 antibody, phospholipid phosphatase 1 antibody, phosphatidic acid phosphatase type 2A antibody, phospholipid phosphatase 1 L homeolog antibody, PLPP1 antibody, plpp1 antibody, Ppap2a antibody, plpp1.L antibody, Plpp1 antibody

Background: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.Synonyms: Lipid phosphate phosphohydrolase 1, PAP2-alpha, PAP2a, Phosphatidate phosphohydrolase type 2a, Phosphatidic acid phosphatase 2a

Gene ID: 8611

NCBI Accession: NP_003702

UniProt: O14494

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway