COL4A3BP antibody

Catalog No. ABIN265284

Product Details anti-COL4A3BP Antibody

Target: COL4A3BP (Collagen, Type IV, alpha 3 (Goodpasture Antigen) Binding Protein (COL4A3BP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL4A3BP antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects CERTL.

Purification: Purified

Immunogen: Synthetic peptide derived from human CERTL protein

Isotype: IgG

Application Details

Application Notes: Western Blot (5-10 μg/mL). Positive control: ovary.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for COL4A3BP

Target: COL4A3BP (Collagen, Type IV, alpha 3 (Goodpasture Antigen) Binding Protein (COL4A3BP))

Alternative Name: COL4A3BP (COL4A3BP Products)

Synonyms: COL4A3BP antibody, 2810404O15Rik antibody, 9230101K08Rik antibody, AU016711 antibody, CERT antibody, GPBP antibody, col4a3bp antibody, wu:fc37f11 antibody, zgc:92147 antibody, CERTL antibody, STARD11 antibody, cert antibody, certl antibody, cetp antibody, gpbp antibody, stard11 antibody, collagen type IV alpha 3 binding protein antibody, collagen, type IV, alpha 3 (Goodpasture antigen) binding protein antibody, collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a antibody, collagen, type IV, alpha 3 (Goodpasture antigen) binding protein L homeolog antibody, COL4A3BP antibody, Col4a3bp antibody, col4a3bpa antibody, col4a3bp.L antibody

Background: CERT mediates the ATP-dependent ER-to-Golgi transfer of ceramide in a non-vesicular manner. The biosynthesis of lipids involves steps that occur in different intracellular compartments. The movement of lipids within these compartments is important in lipid-mediated signalling. Human CERT is identical to a splice variant of human Goodpasture antigen-binding protein (GPBP26). CERT contains a phosphoinositide-binding pleckstrin-homology (PH) domain (which targets CERT to the Golgi by binding phosphatidylinositol-4-phosphate (PtdIns4P)), a middle region, and a putative lipid-transfer-catalysing domain called START. CERT and CERTL can specifically extract ceramide from phospholipid bilayers in a START-domain-dependent manner. CERT interacts with ER membranes and specifically extracts ceramide. CERT catalyses both the specific extraction of ceramide from donor vesicles and its transfer to acceptor vesicles. CERT can associate with the Golgi in a PtdIns4P dependent manner.Synonyms: CERT, Ceramide transfer protein, Collagen type IV alpha-3-binding protein, GPBP, Goodpasture antigen-binding protein, STARD11, START domain-containing protein 11, StAR-related lipid transfer protein 11, StARD11, hCERT

Gene ID: 10087

NCBI Accession: NP_001123577

UniProt: Q9Y5P4