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Claudin 5 antibody

CLDN5 Reactivity: Human, Rat, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN265364
  • Target See all Claudin 5 (CLDN5) Antibodies
    Claudin 5 (CLDN5)
    Reactivity
    • 60
    • 39
    • 36
    • 18
    • 17
    • 14
    • 3
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 56
    • 6
    Rabbit
    Clonality
    • 49
    • 13
    Polyclonal
    Conjugate
    • 32
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Claudin 5 antibody is un-conjugated
    Application
    • 33
    • 20
    • 18
    • 13
    • 6
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of Claudin 5 protein. (region surrounding Ser201)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen
    Top Product
    Discover our top product CLDN5 Primary Antibody
  • Application Notes
    ELISA: 1/40000approx. 1/60000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Claudin 5 (CLDN5)
    Alternative Name
    Claudin-5 / CLDN5 (CLDN5 Products)
    Synonyms
    AWAL antibody, BEC1 antibody, CPETRL1 antibody, TMVCF antibody, cld5 antibody, awal antibody, bec1 antibody, claudin-5 antibody, cpetrl1 antibody, tmvcf antibody, AI854493 antibody, MBEC1 antibody, Tmvcf antibody, cldn5 antibody, zgc:85723 antibody, zgc:103419 antibody, claudin 5 antibody, Claudin-5 antibody, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) antibody, claudin 5a antibody, claudin 5b antibody, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) L homeolog antibody, CLDN5 antibody, cld5 antibody, cldn5 antibody, Cldn5 antibody, cldn5a antibody, cldn5b antibody, cldn5.L antibody
    Background
    The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrone, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.The human claudin-5 gene maps to chromosome 22q11.21.Synonyms: AWAL, Bec1, Brain endothelial cell clone 1 protein, Lung-specific membrane protein, TMDVCF, TMVCF, Transmembrane protein deleted in VCFS
    Molecular Weight
    approx. 23 kDa
    Gene ID
    7122
    NCBI Accession
    NP_001124333
    UniProt
    O00501
    Pathways
    Hepatitis C
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