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Fibrillin 1 antibody

FBN1 Reactivity: Human, Mouse, Rat IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN265420
  • Target See all Fibrillin 1 (FBN1) Antibodies
    Fibrillin 1 (FBN1)
    Reactivity
    • 61
    • 30
    • 21
    • 10
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 70
    • 14
    • 1
    Rabbit
    Clonality
    • 71
    • 14
    Polyclonal
    Conjugate
    • 45
    • 16
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Fibrillin 1 antibody is un-conjugated
    Application
    • 58
    • 30
    • 30
    • 18
    • 14
    • 14
    • 13
    • 13
    • 12
    • 9
    • 5
    • 3
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of Fibrillin-1 protein. (region surrounding asn2843)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product FBN1 Primary Antibody
  • Application Notes
    ELISA: 1/40000-1/60000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Bell, Gendron, Anderson, Flatow, Andarawis-Puri: "A potential new role for myofibroblasts in remodeling of sub-rupture fatigue tendon injuries by exercise." in: Scientific reports, Vol. 8, Issue 1, pp. 8933, (2018) (PubMed).

  • Target
    Fibrillin 1 (FBN1)
    Alternative Name
    Fibrillin-1 (FBN1 Products)
    Synonyms
    FBN1 antibody, ACMICD antibody, ECTOL1 antibody, FBN antibody, GPHYSD2 antibody, MASS antibody, MFS1 antibody, OCTD antibody, SGS antibody, SSKS antibody, WMS antibody, WMS2 antibody, AI536462 antibody, B430209H23 antibody, Fib-1 antibody, Tsk antibody, fibrillin 1 antibody, FBN1 antibody, Fbn1 antibody
    Background
    The fibrillin family of proteins, including fibrillin-1 (FBN1) and fibrillin-2 (FBN2), are integral components of a distinct subset of extracellular microfibrils. Microfibrils are found in elastic tissues where they facilitate elastic fiber formation and in nonelastic tissue where they support the association of the epithelial cells with the interstitial matrix. Characteristic of the fibrillin proteins are the epidermal growth factor (EGF)-like motifs, which contain a consensus sequence for calcium binding. This calcium association may be critical for protein-protein interactions and stabilization of the microfibrils. Mutations of the FBN1 gene have been shown to result in Marfan syndrome, a disease characterized by abnormal synthesis, secretion and matrix deposition of fibrillin. FBN2 is also linked to a rare, yet similiar, skeletal disorder, congenital contractural arachnodactyly.Synonyms: FBN, FBN1
    Gene ID
    2200
    NCBI Accession
    NP_000129
    UniProt
    P35555
    Pathways
    Maintenance of Protein Location, SARS-CoV-2 Protein Interactome
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