HSV ICP27 antibody

Catalog No. ABIN265583

Product Details anti-HSV ICP27 Antibody

Target: HSV ICP27 (Herpes Simplex Virus ICP27 (HSV ICP27))

Reactivity: Herpes Simplex Virus (HSV)

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSV ICP27 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Characteristics: Mouse monoclonal antibody to ICP27 of Herpes Simplex Virus. This antibody originates from ascites fluids and is purified by protein G agarose affinity chromatography.

Purification: Protein G agarose affinity chromatography

Clone: H1113

Isotype: IgG1 kappa

Application Details

Application Notes: Reactive with ICP27 of Herpes Simplex Virus in immunofluorescence (IFA) and western blot at 10 ug/ml.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/ml

Buffer: Phosphate Buffered Saline pH 7.4 (no azide)

Preservative: Azide free

Storage: -20 °C

References for anti-HSV ICP27 antibody (ABIN265583)

Park, Lengyel, Rice: "The role of immediate-early protein ICP27 in the differential sensitivity of herpes simplex viruses type-1 and type-2 to leptomycin B." in: Journal of virology, (2013) (PubMed).

Malik, Tabarraei, Kehlenbach, Korfali, Iwasawa, Graham, Schirmer: "Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways." in: The Journal of biological chemistry, Vol. 287, Issue 15, pp. 12277-92, (2012) (PubMed).

Jurak, Silverstein, Sharma, Coen: "Herpes Simplex Virus Is Equipped with RNA- and Protein-Based Mechanisms To Repress Expression of ATRX, an Effector of Intrinsic Immunity." in: Journal of virology, Vol. 86, Issue 18, pp. 10093-102, (2012) (PubMed).

Jin, Yan, Ma, Cao, He: "An Herpesvirus Virulence Factor Inhibits Dendritic Cell Maturation Through Protein Phosphatase 1 and I{kappa}B Kinase." in: Journal of virology, (2011) (PubMed).

Luganini, Nicoletto, Pizzuto, Pirri, Giuliani, Landolfo, Gribaudo: "Inhibition of herpes simplex virus type 1 and type 2 infections by peptide-derivatized dendrimers." in: Antimicrobial agents and chemotherapy, Vol. 55, Issue 7, pp. 3231-9, (2011) (PubMed).

Salaun, MacDonald, Larralde, Howard, Lochtie, Burgess, Brook, Malik, Gray, Graham: "Poly(A)-binding protein 1 partially relocalizes to the nucleus during herpes simplex virus type 1 infection in an ICP27-independent manner and does not inhibit virus replication." in: Journal of virology, Vol. 84, Issue 17, pp. 8539-48, (2010) (PubMed).

Target Details for HSV ICP27

Target: HSV ICP27 (Herpes Simplex Virus ICP27 (HSV ICP27))

Abstract: HSV ICP27 Products

Target Type: Viral Protein

Background: Herpes simplex virus (HSV) ICP27 (Infected cell polypeptide 27) is an essential and multifunctional regulator of viral gene expression that modulates RNA splicing,polyadenylation, and nuclear export. ICP27 Belongs to the herpes viruses UL69 family. It is involved in the down-regulation of viral immediate-early genes and acts incombination with ICP0 and ICP4 as an activator of late genes. Alternate Names: anti-Herpes simplex virus 1 ICP27 antibody, anti-Herpes simplex virus 1 transcriptional regulator IE63 antibody, anti-Herpes simplex virus 2 ICP27 antibody, anti-Herpessimplex virus 2 transcriptional regulator IE63 antibody