BCL2 antibody (B-Cell CLL/lymphoma 2) (AA 41-54) (PE)

Details for Product anti-BCL2 Antibody No. ABIN2662398, Supplier: Log in to see
Antigen
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • BCL2, apoptosis regulator
  • B cell leukemia/lymphoma 2
  • B-cell CLL/lymphoma 2a
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • bcl2a
  • BCL-2
Alternatives
anti-Human BCL2 antibody for Flow Cytometry
Epitope
AA 41-54
178
77
64
64
40
29
27
26
24
21
16
15
15
15
11
11
9
9
9
9
8
7
7
7
7
6
5
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
1141
275
249
55
26
24
19
18
7
4
3
3
3
2
2
2
Host
Mouse
632
585
19
6
2
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This BCL2 antibody is conjugated to PE
57
56
45
43
36
25
24
17
16
15
14
14
14
14
14
14
13
13
11
11
7
7
7
6
6
6
6
6
6
6
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Flow Cytometry (FACS)
912
440
424
408
360
355
247
209
180
81
42
33
15
13
12
11
9
3
3
2
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen AA 41-54 of human bcl-2 oncoprotein
Clone 100
Isotype IgG1
Purification The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Alternative Name Bcl-2 (BCL2 Antibody Abstract)
Background Bcl-2 is a conserved anti-apoptotic protein that plays important roles in normal immunity. It forms homodimers or heterodimers with other Bcl-2 family members. This protein regulates apoptosis through controlling mitochondrial fusion and fission. Phosphorylation of Bcl-2 has been shown to enhance activity to allow response to extracellular growth-factor-mediated signals. Bcl-2 is also regulated by IRES, miR-15a, miR-16-1 and RNA-BP nucleolin. Chromosome 18q21.3 translocation and overexpression of Bcl-2 is frequently observed in follicular lymphomas and some diffuse large B-cell lymphomas.
Pathways MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.
Supplier Images
Flow Cytometry (FACS) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody (PE) (ABIN2662398) anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody (PE)
Background publications Lin, Medeiros: "The impact of MYC rearrangements and "double hit" abnormalities in diffuse large B-cell lymphoma." in: Current hematologic malignancy reports, Vol. 8, Issue 3, pp. 243-52, 2013 (PubMed).

Kelly, Strasser: "The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy." in: Cell death and differentiation, Vol. 18, Issue 9, pp. 1414-24, 2011 (PubMed).

Tomita: "BCL2 and MYC dual-hit lymphoma/leukemia." in: Journal of clinical and experimental hematopathology : JCEH, Vol. 51, Issue 1, pp. 7-12, 2011 (PubMed).

Rolland, Conradt: "New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics." in: Current opinion in cell biology, Vol. 22, Issue 6, pp. 852-8, 2010 (PubMed).

Willimott, Wagner: "Post-transcriptional and post-translational regulation of Bcl2." in: Biochemical Society transactions, Vol. 38, Issue 6, pp. 1571-5, 2010 (PubMed).

Pezzella, Turley, Kuzu, Tungekar, Dunnill, Pierce, Harris, Gatter, Mason: "bcl-2 protein in non-small-cell lung carcinoma." in: The New England journal of medicine, Vol. 329, Issue 10, pp. 690-4, 1993 (PubMed).

Pezzella, Tse, Cordell, Pulford, Gatter, Mason: "Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation." in: The American journal of pathology, Vol. 137, Issue 2, pp. 225-32, 1990 (PubMed).

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