IL2 Receptor beta antibody (Biotin)

Catalog No. ABIN2688931

Product Details anti-IL2 Receptor beta Antibody (Biotin)

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL2 Receptor beta antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: The Mik-β3 clone reacts with CD122, the p75 (β chain) of the human high affinity receptor for interleukin 2 (IL-2Rβ), a 70-75 kD type I transmembrane protein expressed on mature T- and pre-B-cell subsets, thymocytes, monocytes, hematopoietic progenitor cells, fetal liver cells and stromal cells. The IL-2Rβ plays a role in B-cell proliferation, T-cell proliferation and activation. Profile of peripheral blood lymphocytes analyzed on a FACScan

BD Pharmingen™ Biotin Mouse Anti-Human CD122 - Biotin - Clone Mik-β3 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: Mik

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

References for anti-IL2 Receptor beta antibody (Biotin) (ABIN2688931)

Ishikawa, Uchiyama, Kamio, Onishi, Kodaka, Okuma: "IL-4 down-regulates IL-2 receptor p75 by accelerating its endocytosis." in: International immunology, Vol. 3, Issue 6, pp. 517-25, (1991) (PubMed).

Tsudo, Kitamura, Miyasaka: "Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 6, pp. 1982-6, (1989) (PubMed).

Guesdon, Ternynck, Avrameas: "The use of avidin-biotin interaction in immunoenzymatic techniques." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).

Target Details for IL2 Receptor beta

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Alternative Name: CD122 (IL2RB Products)

Synonyms: IL2RB antibody, il-2rb antibody, CD122 antibody, IL15RB antibody, P70-75 antibody, IL2RBC antibody, IL-15Rbeta antibody, IL15Rbeta antibody, Il-2/15Rbeta antibody, Il-2Rbeta antibody, p70 antibody, interleukin 2 receptor subunit beta antibody, interleukin-2 receptor subunit beta antibody, interleukin 2 receptor, beta antibody, interleukin 2 receptor, beta chain antibody, IL2RB antibody, LOC510185 antibody, il2rb antibody, Il2rb antibody

Background: Synonyms: IL-2 Receptor β chain, p75

Pathways: JAK-STAT Signaling, Growth Factor Binding