FLT3 antibody

Catalog No. ABIN2688960

Product Details anti-FLT3 Antibody

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FLT3 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with FMS-like tyrosine kinase 3 (flt3), a 155-160 kD, class III tyrosine kinase receptor (CD135), which is structurally related to the receptors for PDGF, SCF-1 and kit ligand. CD135 is expressed on multipotential, myelomonocytic and primitive B-cell progenitors. The most primitive hematopoietic progenitor cells express low levels of CD135. CD135 plays the role of growth factor receptor for early hematopoietic progenitors. Reports from studies with knockout mice have shown that targeted CD135 disruption impaired the development of primitive progenitor cells of all hematopoietic lineages with significant impact on lymphopoietic precursors. Profile of REH cell line analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD135 - Purified - Clone 4G8 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: 4G8

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-FLT3 antibody (ABIN2688960)

Rappold, Ziegler, Köhler, Marchetto, Rosnet, Birnbaum, Simmons, Zannettino, Hill, Neu, Knapp, Alitalo, Alitalo, Ullrich, Kanz, Bühring: "Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase." in: Blood, Vol. 90, Issue 1, pp. 111-25, (1997) (PubMed).

Rusten, Lyman, Veiby, Jacobsen: "The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro." in: Blood, Vol. 87, Issue 4, pp. 1317-25, (1996) (PubMed).

Mackarehtschian, Hardin, Moore, Boast, Goff, Lemischka: "Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors." in: Immunity, Vol. 3, Issue 1, pp. 147-61, (1995) (PubMed).

Rosnet, Schiff, Pébusque, Marchetto, Tonnelle, Toiron, Birg, Birnbaum: "Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells." in: Blood, Vol. 82, Issue 4, pp. 1110-9, (1993) (PubMed).

Target Details for FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: CD135 (FLT3 Products)

Synonyms: FLT3 antibody, B230315G04 antibody, CD135 antibody, Flk-2 antibody, Flk2 antibody, Flt-3 antibody, Ly72 antibody, wmfl antibody, FLK-2 antibody, FLK2 antibody, STK1 antibody, fms related tyrosine kinase 3 antibody, FMS-like tyrosine kinase 3 antibody, fms-related tyrosine kinase 3 antibody, FLT3 antibody, Flt3 antibody

Pathways: RTK Signaling