CD137 antibody (Tumor Necrosis Factor Receptor Superfamily, Member 9)

Details for Product anti-TNFRSF9 Antibody No. ABIN2688961, Supplier: Log in to see
Antigen
  • TNFRSF9
  • zgc:136557
  • 4-1BB
  • CD137
  • CDw137
  • ILA
  • A930040I11Rik
  • AA408498
  • AI325004
  • Cd137
  • Ly63
  • tumor necrosis factor receptor superfamily member 9
  • TNF receptor superfamily member 9
  • tumor necrosis factor receptor superfamily, member 9a
  • tumor necrosis factor receptor superfamily, member 9
  • TNFRSF9
  • tnfrsf9a
  • Tnfrsf9
Reactivity
Human
220
131
21
15
14
10
3
2
2
2
2
2
Host
Mouse
119
108
57
29
19
Clonality (Clone)
Monoclonal ()
Conjugate
This CD137 antibody is un-conjugated
30
23
15
11
11
10
9
9
6
6
6
6
6
6
4
4
4
4
4
4
2
2
1
1
1
1
1
1
1
1
1
Application
ELISA
216
143
98
21
19
16
13
12
8
8
5
5
3
2
2
2
2
2
1
1
Options
Supplier
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Supplier Product No.
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Brand BD Pharmingen™
Clone H41BB
Isotype IgG1, kappa
Characteristics Human 4-1BB, also known as CDw137, is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. Naive T cells lack the 4-1BB, which is not only induced upon T cell activation, but also remains on activated T cells. It has been reported that the expression of 4-1BB is restricted to primed CD4+ and CD8+ cells. When triggered by either 4-1BB ligand or antibody ligation, the 4-1BB molecule can act as a co-stimulator to induce T-cell activation and proliferation. In recent studies, 4-1BB has been emphasized for its effect on the development and survival of functionally active effector CD8 (+) T cells against tumors, virus infections, allogenic immune responses, and for potential therapeutic application.

BD Pharmingen™ Purified Anti-Human CD137 - Purified - Clone h41BB-M127 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD137 (TNFRSF9 Antibody Abstract)
Background Synonyms: 4-1BB, CDw137
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Product cited in: Kim, Broxmeyer: "Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells." in: Journal of hematotherapy & stem cell research, Vol. 10, Issue 4, pp. 441-9, 2001 (PubMed).

Michel, Schwarz: "Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes." in: Cytokine, Vol. 12, Issue 6, pp. 742-6, 2000 (PubMed).

Vinay, Kwon: "Role of 4-1BB in immune responses." in: Seminars in immunology, Vol. 10, Issue 6, pp. 481-9, 1999 (PubMed).

Melero, Shuford, Newby, Aruffo, Ledbetter, Hellström, Mittler, Chen: "Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors." in: Nature medicine, Vol. 3, Issue 6, pp. 682-5, 1997 (PubMed).

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