TNFSF9 antibody

Catalog No. ABIN2688965

Product Details anti-TNFSF9 Antibody

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFSF9 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with a type II membrane protein known as 4-1BB ligand. This molecule belongs to the TNF superfamily. It has been reported to have costimulatory function on activated T cells. Reports suggest that stimulation of activated T cells via 4-1BB ligand does not require the presence of other costimulatory molecules, including CD28. Some studies have reported human 4-1BB ligand to be expressed preferentially on primary B cells and B-cell lines. C65-485 antibody is able to react with recombinant human 4-1BB ligand (rh4-1BBL) bound to CD137 (4-1BB receptor) expressed on PHA-stimulated PBMC. Profile of Hut-78 cell line analzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD137 Ligand - Purified - Clone C65-485 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: C65

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-TNFSF9 antibody (ABIN2688965)

Melero, Bach, Hellström, Aruffo, Mittler, Chen: "Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway." in: European journal of immunology, Vol. 28, Issue 3, pp. 1116-21, (1998) (PubMed).

Chu, DeBenedette, Stiernholm, Barber, Watts: "Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 7, pp. 3081-9, (1997) (PubMed).

DeBenedette, Shahinian, Mak, Watts: "Costimulation of CD28- T lymphocytes by 4-1BB ligand." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 2, pp. 551-9, (1997) (PubMed).

Zhou, Kim, Hurtado, Lee, Kim, Pollok, Kwon: "Characterization of human homologue of 4-1BB and its ligand." in: Immunology letters, Vol. 45, Issue 1-2, pp. 67-73, (1995) (PubMed).

Target Details for TNFSF9

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Alternative Name: CD137 Ligand (TNFSF9 Products)

Synonyms: TNFSF9 antibody, 4-1BB-L antibody, 4-1BBL antibody, AI848817 antibody, Cd137l antibody, Ly63l antibody, CD137L antibody, TNF superfamily member 9 antibody, tumor necrosis factor (ligand) superfamily, member 9 antibody, Tnfsf9 antibody, LOC476729 antibody, TNFSF9 antibody

Background: Synonyms: 4-1BB Ligand

Pathways: Activated T Cell Proliferation, Cancer Immune Checkpoints