CD151 antibody

Catalog No. ABIN2688986

Product Details anti-CD151 Antibody

Target: CD151

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD151 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Brand: BD Pharmingen™

Characteristics: Reacts with platelet-endothelial cell tetraspan antigen-3 (PETA-3), a 27 kD membrane glycoprotein, expressed on platelets, megakaryocytes, lymphocytes (weak), monocytes, endothelial cells and epithelial cells. PETA-3 (CD151) associates with β1 integrin in certain tissues. This has also been shown with other tetraspan superfamily members, like CD9, CD63 and α5β1. Reports indicate that this association or colocalization of CD151 with β1 integrin in tissues suggests a functional role of this molecule, however, this role has not been elucidated yet. It has also been reported that antibody 14A2.H1 is capable of platelet activation in vitro. Studies showed that different clones of CD151 monoclonal antibodies display strikingly different patterns of binding to human haemopoietic cells and tissue sections, and that this is due at least in part to the presence of the protein in complexes with different integrins. Profile of peripheral blood platelets analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD151 - Purified - Clone 14A2.H1 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: 14A2-H1

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD151 antibody (ABIN2688986)

Geary, Cambareri, Sincock, Fitter, Ashman: "Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies." in: Tissue antigens, Vol. 58, Issue 3, pp. 141-53, (2001) (PubMed).

Sincock, Mayrhofer, Ashman: "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 45, Issue 4, pp. 515-25, (1997) (PubMed).

Fitter, Tetaz, Berndt, Ashman: "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3." in: Blood, Vol. 86, Issue 4, pp. 1348-55, (1995) (PubMed).

Target Details for CD151

Target: CD151

Alternative Name: CD151 (CD151 Products)

Synonyms: CD151 antibody, MGC83668 antibody, gp27 antibody, mer2 antibody, raph antibody, sfa1 antibody, peta-3 antibody, tspan24 antibody, PETA-3 antibody, SFA-1 antibody, Tspan24 antibody, GP27 antibody, MER2 antibody, RAPH antibody, SFA1 antibody, TSPAN24 antibody, CD151 molecule antibody, CD151 molecule (Raph blood group) L homeolog antibody, CD151 molecule (Raph blood group) antibody, CD151 antigen antibody, CD151 antibody, cd151.L antibody, cd151 antibody, Cd151 antibody

Background: Synonyms: PETA-3