Reacts with DEC-205, a 205 kDa transmembrane protein with C-type lectin external domains, present on dendritic cells (DC) and some epithelia. It is being described as a multilectin receptor for adsorptive endocytosis. Reports indicate that CD205 (DEC-205) mRNA levels increase significantly during activation. In monocyte derived dendritic cells, the expression of CD205 increased during maturation. Antibody MMRI-7 is useful for the study of DC development. Profile of CD205 (MMRI-7) reactivity on peripheral blood monocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C.
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Guo, Gong, Maric, Misulovin, Pack, Mahnke, Nussenzweig, Steinman: "A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells." in: Human immunology, Vol. 61, Issue 8, pp. 729-38, (2000) (PubMed).
Kato, Neil, Clark, Morris, Sorg, Hart: "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells." in: Immunogenetics, Vol. 47, Issue 6, pp. 442-50, (1998) (PubMed).