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CD4 antibody

CD4 Reactivity: Human FACS, IHC (fro), IHC (p), IHC (zinc) Host: Mouse Monoclonal RPA unconjugated
Catalog No. ABIN2689229
  • Target See all CD4 Antibodies
    CD4
    Reactivity
    • 355
    • 199
    • 113
    • 38
    • 24
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    Human
    Host
    • 328
    • 146
    • 108
    • 4
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    • 1
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    Mouse
    Clonality
    • 445
    • 138
    • 3
    Monoclonal
    Conjugate
    • 195
    • 65
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    This CD4 antibody is un-conjugated
    Application
    • 470
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    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc))
    Brand
    BD Pharmingen™
    Characteristics
    The RPA-T4 monoclonal antibody specifically binds to CD4, a 59 kDa single-chain transmembrane glycoprotein that is expressed on T-helper/inducer cell populations. CD4 is also expressed on thymocytes subsets and at lower levels on monocytes and macrophages. CD4 functions as a co-receptor in MHC class II-restricted antigen-induced T cell activation and as a receptor for human immunodeficiency viruses (HIV). This antibody binds to the D1 domain (CDR1 and CDR3 epitopes) of the CD4 antigen and reacts with approximately 80 % of thymocytes and 45 % of peripheral blood lymphocytes. CD4 is also present in low density on peripheral blood monocytes. RPA-T4 is capable of blocking HIV-1, gp120, and inhibits syncytium formation. Immunohistochemical staining of CD4+ T lymphocytes: Frozen sections of normal human tonsil was reacted with the RPA-T4 antibody. CD4+ T lymphocytes can be identified by the intense brown labeling of their cell membranes.

    BD Pharmingen™ Purified Mouse Anti-Human CD4 - Purified - Clone RPA-T4 - Isotype Mouse IgG1, κ - Reactivity Hu - 1 mL
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Clone
    RPA
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD4 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    31.25 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Target
    CD4
    Alternative Name
    CD4 (CD4 Products)
    Synonyms
    cd4 antibody, L3T4 antibody, Ly-4 antibody, CD4mut antibody, W3/25 antibody, p55 antibody, CD4 molecule antibody, carcinoembryonic antigen-related cell adhesion molecule 5 antibody, T-cell surface glycoprotein CD4 antibody, CD4 antigen antibody, Cd4 molecule antibody, CD4 antibody, LOC100125525 antibody, cd4 antibody, Cd4 antibody
    Pathways
    TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events
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