CD42a antibody

Catalog No. ABIN2689252

Product Details anti-CD42a Antibody

Target: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD42a antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with a 17-22kD, single chain integral membrane glycoprotein, also known as GPIX. CD42a forms a noncovalently linked complex (GPIb/GPIX/GPV) with CD42b, CD42c and CD42d. It is expressed on platelets and megakaryocytes and is absent on the platelets of patients with Bernadr-Soulier Syndrome (BSS). Although the CD42a function is not fully understood, GPIX glycoprotein is important for the assembly and membrane expression of the complex and for the maintenance of the functional conformation of CD42b (GPIb). Profile of resting platelets analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD42a - Purified - Clone ALMA.16 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: ALMA-16

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD42a antibody (ABIN2689252)

Schick, Walker: "The acylation of megakaryocyte proteins: glycoprotein IX is primarily myristoylated while glycoprotein Ib is palmitoylated." in: Blood, Vol. 87, Issue 4, pp. 1377-84, (1996) (PubMed).

Hickey, Williams, Roth: "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 17, pp. 6773-7, (1989) (PubMed).

Fox, Aggerbeck, Berndt: "Structure of the glycoprotein Ib.IX complex from platelet membranes." in: The Journal of biological chemistry, Vol. 263, Issue 10, pp. 4882-90, (1988) (PubMed).

Target Details for CD42a

Target: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Alternative Name: CD42a (GP9 Products)

Synonyms: cd42a antibody, gpix antibody, GP9 antibody, GPIX antibody, Cd42 antibody, CD42a antibody, glycoprotein IX platelet antibody, glycoprotein IX platelet L homeolog antibody, glycoprotein IX (platelet) antibody, glycoprotein 9 (platelet) antibody, GP9 antibody, gp9.L antibody, Gp9 antibody