CEACAM1 antibody

Catalog No. ABIN2689374

Product Details anti-CEACAM1 Antibody

Target: CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CEACAM1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with a 35 and a 180 kDa glycosylphosphatidylinositol-anchored glycoprotein present on granulocytes and epithelial cells. Antibody COL-1 was studied as recognizing CD66d and CD66e in the VI Human Leukocyte Differentiation Workshop. CD66 antigens also known as the carcinoembryonic antigen (CEA) family of molecules, are closely related to the immunoglobulin superfamily of glycoproteins. Studies on CD66 Molecules suggest a potential adhesion function in vivo. These molecules exhibit both homophilic and heterophilic ashesion. CEA family members may be involved in transmembrane signalling and activation of neutrophils. Profile of peripheral blood granulocytes analyzed by flow cytometry. Second step staining with biotinylated goat anti-mouse Ig's, third step staining with Streptavidin-PE.

BD Pharmingen™ Purified Mouse Anti-Human CD66 - Purified - Clone COL-1 - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: COL

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CEACAM1 antibody (ABIN2689374)

Siler, Eggensperger, Hand, Milenic, Miller, Houchens, Hinkle, Schlom: "Therapeutic efficacy of a high-affinity anticarcinoembryonic antigen monoclonal antibody (COL-1)." in: Biotechnology therapeutics, Vol. 4, Issue 3-4, pp. 163-81, (1994) (PubMed).

Nagel, Grunert, Kuijpers, Watt, Thompson, Zimmermann: "Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family." in: European journal of biochemistry / FEBS, Vol. 214, Issue 1, pp. 27-35, (1993) (PubMed).

Thompson, Grunert, Zimmermann: "Carcinoembryonic antigen gene family: molecular biology and clinical perspectives." in: Journal of clinical laboratory analysis, Vol. 5, Issue 5, pp. 344-66, (1991) (PubMed).

Target Details for CEACAM1

Target: CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))

Alternative Name: CD66 (CEACAM1 Products)

Synonyms: BGP antibody, BGP1 antibody, BGPI antibody, CD66e antibody, CEA antibody, zeh0068 antibody, hm:zeh0068 antibody, CEACAM8 antibody, CEACAM1 antibody, MGC142545 antibody, BGPR antibody, Bgp antibody, CD66a antibody, Ccam1 antibody, Bgp1 antibody, C-CAM antibody, Cc1 antibody, Cea-1 antibody, Cea-7 antibody, Cea1 antibody, Cea7 antibody, Hv-2 antibody, Hv2 antibody, MHVR antibody, MHVR1 antibody, Mhv-1 antibody, bb-1 antibody, mCEA1 antibody, mmCGM1 antibody, mmCGM1a antibody, mmCGM2 antibody, carcinoembryonic antigen related cell adhesion molecule 1 antibody, carcinoembryonic antigen related cell adhesion molecule 5 antibody, carcinoembryonic antigen-related cell adhesion molecule 1 antibody, carcinoembryonic antigen-related cell adhesion molecule 6 antibody, CEACAM1 antibody, CEACAM5 antibody, ceacam1 antibody, Ceacam1 antibody, LOC101103343 antibody

Background: Synonyms: CEA, carcinoembryonic antigen