CEACAM6 antibody (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen))

Details for Product anti-CEACAM6 Antibody No. ABIN2689376, Supplier: Log in to see
Antigen
  • CD66c
  • CEAL
  • NCA
  • carcinoembryonic antigen-related cell adhesion molecule 6
  • carcinoembryonic antigen related cell adhesion molecule 6
  • Ceacam6
  • CEACAM6
Reactivity
Human
109
24
6
1
Host
Mouse
65
44
Clonality (Clone)
Monoclonal ()
Conjugate
This CEACAM6 antibody is un-conjugated
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7
7
5
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
62
56
46
36
4
4
3
3
2
2
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Brand BD Pharmingen™
Clone B6-2-CD66
Isotype IgG1, kappa
Characteristics Reacts with two glycosylphosphatidylinositol-anchored glycoprotein present on granulocytes. Antibody B6.2 was studied as recognizing CD66c in the VI Human Leukocyte Differentiation Antigen workshop. CD66 antigens also known as the carcinoembryonic antigen (CEA) family of molecules, are closely related to the immunoglobulin super family of glycoproteins. Studies on CD66 Molecules suggest a potential adhesion function in vivo. These molecules exhibit both homophilic and heterophilic adhesion. CEA family members may be involved in transmembrane signalling and activation of neutrophils. This clone has been found to be N-terminal domain reactive, reacted preferentially with the native protein and were conformationally dependent. Profile of peripheral blood granulocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD66c - Purified - Clone B6.2/CD66 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Plasmids, Primers & others Plasmids, Primers & others CEACAM6 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD66c (CEACAM6 Antibody Abstract)
Background Synonyms: CEA, carcinoembryonic antigen
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Product cited in: Watt, Teixeira, Zhou, Doyonnas, Zhang, Grunert, Blumberg, Kuroki, Skubitz, Bates: "Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site." in: Blood, Vol. 98, Issue 5, pp. 1469-79, 2001 (PubMed).

Skubitz, Campbell, Ahmed, Skubitz: "CD66 family members are associated with tyrosine kinase activity in human neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 11, pp. 5382-90, 1995 (PubMed).

Kuroki, Arakawa, Matsuo, Oikawa, Misumi, Nakazato, Matsuoka: "Molecular cloning of nonspecific cross-reacting antigens in human granulocytes." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11810-7, 1991 (PubMed).

Thompson, Grunert, Zimmermann: "Carcinoembryonic antigen gene family: molecular biology and clinical perspectives." in: Journal of clinical laboratory analysis, Vol. 5, Issue 5, pp. 344-66, 1991 (PubMed).

Szpak, Johnston, Lottich, Kufe, Thor, Schlom: "Patterns of reactivity of four novel monoclonal antibodies (B72.3, DF3, B1.1 and B6.2) with cells in human malignant and benign effusions." in: Acta cytologica, Vol. 28, Issue 4, pp. 356-67, 1984 (PubMed).

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