LILRB1 antibody

Catalog No. ABIN2689417

Product Details anti-LILRB1 Antibody

Target: LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LILRB1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Fluorescence Microscopy (FM)

Brand: BD Pharmingen™

Characteristics: CD85 Molecules belong to a large immunoregulatory family and it has been clustered into different subclasses from CD85a to CD85m in the VIIth HLDA workshop. CD85j is also called as Ig-like transcript (ILT2), or leukocyte Ig-like receptor (LIR-1). Reacts with an 110 kDa membrane glycoprotein expressed on a subset of NK cells, which varies amongst individuals, and a subpopulation of T lymphocytes. Expression on T lymphocytes, NK cells may depend on the individuals tested. Function studies show that ligation of ILT2 with MHC class I including HLA-A, B, G1 and -E induces an inhibitory signal via recruitment of SHP-1 phosphatase. This antibody is routinely tested by flow cytometric analysis and fluorescence microscopy. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD85j - Purified - Clone GHI/75 - Isotype Mouse IgG2b, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: GHI-75

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-LILRB1 antibody (ABIN2689417)

Colonna, Nakajima, Navarro, López-Botet: "A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells." in: Journal of leukocyte biology, Vol. 66, Issue 3, pp. 375-81, (1999) (PubMed).

Pulford, Micklem, Thomas, Jones, Mason: "A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms." in: Clinical and experimental immunology, Vol. 85, Issue 3, pp. 429-35, (1991) (PubMed).

McArdle, Knight, Halliday, Muller, Rowden: "Quantitative assessment of Langerhans cells in actinic keratosis, Bowen's disease, keratoacanthoma, squamous cell carcinoma and basal cell carcinoma." in: Pathology, Vol. 18, Issue 2, pp. 212-6, (1986) (PubMed).

Target Details for LILRB1

Target: LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))

Alternative Name: CD85j (LILRB1 Products)

Synonyms: CD85J antibody, ILT-2 antibody, ILT2 antibody, LIR-1 antibody, LIR1 antibody, MIR-7 antibody, MIR7 antibody, leukocyte immunoglobulin like receptor B1 antibody, LILRB1 antibody

Background: Synonyms: CD85

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response