IL12B antibody

Catalog No. ABIN2689727

Product Details anti-IL12B Antibody

Target: IL12B (Interleukin 12 beta (IL12B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL12B antibody is un-conjugated

Application: ELISA

Brand: BD Pharmingen™

Characteristics: The C8.3 antibody reacts with human IL-12 p40 subunit but not IL-12 p70 heterodimer or IL-12 p35 monomer. The immunogen used to generate the C8.3 hybridoma was the purified p40 subunit of human IL-12. The C8.3 antibody has been reported not to bind p40 chain when it is complexed to p35 (i.e., the p70 heterodimer). The combination of anti-p40 antibodies, C8.3 and C8.6 , has been reported to yield an assay for detecting only free p40 chain, and specifically not the p70 heterodimer. It has been reported that activated PBMC produce an excess of the free p40 protein over the p70 heterodimer.

BD Pharmingen™ Purified Mouse Anti-Human IL-12 (p40) - Purified - Clone C8.3 - Isotype Mouse IgG1, κ - Reactivity Hu - 1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Purified human IL-12 p40 subunit

Clone: C8-3

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-IL12B antibody (ABIN2689727)

DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).

Target Details for IL12B

Target: IL12B (Interleukin 12 beta (IL12B))

Alternative Name: IL-12 p40 (IL12B Products)

Synonyms: CLMF antibody, CLMF2 antibody, IL-12B antibody, NKSF antibody, NKSF2 antibody, p40 antibody, Il-12b antibody, Il12p40 antibody, Il-12p40 antibody, Il12 antibody, IL-12p40 antibody, IL-12 antibody, IL-12 p40 antibody, il12b antibody, il12p40.b antibody, zgc:152789 antibody, IL-12.p40 antibody, IL12p40 antibody, IL12B antibody, CLMF p40 antibody, interleukin 12B antibody, interleukin 12b antibody, interleukin 12Ba antibody, IL12B antibody, Il12b antibody, il12ba antibody

Pathways: JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation