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CD56 antibody

NCAM1 Reactivity: Human FACS, IHC (f) Host: Mouse Monoclonal R19 unconjugated
Catalog No. ABIN2689855
  • Target See all CD56 (NCAM1) Antibodies
    CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
    Reactivity
    • 234
    • 70
    • 66
    • 26
    • 18
    • 14
    • 12
    • 10
    • 10
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    Human
    Host
    • 152
    • 89
    • 2
    • 1
    Mouse
    Clonality
    • 169
    • 74
    • 1
    Monoclonal
    Conjugate
    • 93
    • 15
    • 13
    • 13
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD56 antibody is un-conjugated
    Application
    • 149
    • 129
    • 55
    • 46
    • 45
    • 34
    • 33
    • 31
    • 27
    • 26
    • 14
    • 14
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Brand
    BD Pharmingen™
    Characteristics
    The R19-760 monoclonal antibody specifically binds to NCAM-1 (Neural cell adhesion molecule 1) that is also known as CD56 and NKH1. NCAM-1 is a heavily glycosylated transmembrane protein and a member of the Ig supergene family. NCAM-1 represents an isoform of the neural cell adhesion molecule (NCAM). In the hematopoietic system, it is present on approximately 10 % to 25 % of peripheral blood lymphocytes. It is expressed on natural killer (NK) cells and a subset of T cells, NKT cells. It is not expressed on myeloid cells, erythrocytes or B cells. This molecule appears to function as an adhesion molecule and can serve as a panspecific NK-cell marker. The R19-760 antibody recognizes an epitope in the NCAM-1 (CD56) extracellular domain that resists destruction due to cellular fixation with BD Phosflow™ Lyse/Fix Buffer and permeabilization with BD Phosflow™ Perm Buffer III. Analyses of NCAM-1 (CD56) expression by Immunohistochemistry and

    BD Pharmingen™ Purified Mouse Anti-Human NCAM-1 (CD56) - Purified - Clone R19-760 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human NCAM1 Recombinant Protein
    Clone
    R19
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product NCAM1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Gerosa, Baldani-Guerra, Nisii, Marchesini, Carra, Trinchieri: "Reciprocal activating interaction between natural killer cells and dendritic cells." in: The Journal of experimental medicine, Vol. 195, Issue 3, pp. 327-33, (2002) (PubMed).

    Galandrini, Tassi, Mattia, Lenti, Piccoli, Frati, Santoni: "SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells." in: Blood, Vol. 100, Issue 13, pp. 4581-9, (2002) (PubMed).

    Cooper, Fehniger, Caligiuri: "The biology of human natural killer-cell subsets." in: Trends in immunology, Vol. 22, Issue 11, pp. 633-40, (2001) (PubMed).

    Bennett, Zatsepina, Zamai, Azzoni, Mikheeva, Perussia: "Definition of a natural killer NKR-P1A+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12." in: The Journal of experimental medicine, Vol. 184, Issue 5, pp. 1845-56, (1996) (PubMed).

    Lanier, Chang, Azuma, Ruitenberg, Hemperly, Phillips: "Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 12, pp. 4421-6, (1991) (PubMed).

    Nitta, Yagita, Sato, Okumura: "Involvement of CD56 (NKH-1/Leu-19 antigen) as an adhesion molecule in natural killer-target cell interaction." in: The Journal of experimental medicine, Vol. 170, Issue 5, pp. 1757-61, (1989) (PubMed).

    Lanier, Testi, Bindl, Phillips: "Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule." in: The Journal of experimental medicine, Vol. 169, Issue 6, pp. 2233-8, (1989) (PubMed).

    Schubert, Zimmermann, Cramer, Starzinski-Powitz: "Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human skeletal muscle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 1, pp. 307-11, (1989) (PubMed).

    Cunningham, Hemperly, Murray, Prediger, Brackenbury, Edelman: "Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing." in: Science (New York, N.Y.), Vol. 236, Issue 4803, pp. 799-806, (1987) (PubMed).

    Edelman: "Cell adhesion molecules in the regulation of animal form and tissue pattern." in: Annual review of cell biology, Vol. 2, pp. 81-116, (1987) (PubMed).

    Phillips, Lanier: "Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis." in: The Journal of experimental medicine, Vol. 164, Issue 3, pp. 814-25, (1986) (PubMed).

    Lanier, Le, Civin, Loken, Phillips: "The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 136, Issue 12, pp. 4480-6, (1986) (PubMed).

  • Target
    CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
    Alternative Name
    NCAM-1 CD56 (NCAM1 Products)
    Synonyms
    CD56 antibody, MSK39 antibody, NCAM antibody, fj56g09 antibody, ncam antibody, ncam1 antibody, wu:fj56g09 antibody, NCAM1 antibody, n-cam antibody, E-NCAM antibody, NCAM-1 antibody, Ncam antibody, Cd56 antibody, N-CAM antibody, N-CAM-1 antibody, NCAM-C antibody, NCAMC antibody, N-CAM-1-B antibody, NCAM-1-B antibody, ncam1-a antibody, ncam1-b antibody, neural cell adhesion molecule 1 antibody, neural cell adhesion molecule 1a antibody, neural cell adhesion molecule 1 S homeolog antibody, neural cell adhesion molecule 1 L homeolog antibody, NCAM1 antibody, ncam1a antibody, ncam1 antibody, LOC100085373 antibody, ncam1.S antibody, Ncam1 antibody, ncam1.L antibody
    Background
    Synonyms: N-CAM-1, Neural cell adhesion molecule 1, NKH1, MSK39, Leu-19
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