Bestrophin 3 antibody

Catalog No. ABIN2716601

Product Details anti-Bestrophin 3 Antibody

Target: Bestrophin 3 (BEST3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Bestrophin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Characteristics: Homo sapiens bestrophin 3 (BEST3), transcript variant 2

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human BEST3 (NP_689652) produced in HEK293T cell.

Clone: 2H3

Isotype: IgG1

Application Details

Application Notes: WB 1:2000, IF 1:100, FLOW 1:100

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for Bestrophin 3

Target: Bestrophin 3 (BEST3)

Alternative Name: BEST3 (BEST3 Products)

Synonyms: CG12327 antibody, Dmel\\CG12327 antibody, dbest3 antibody, best-3 antibody, BEST3 antibody, VMD2L3 antibody, Vmd2l3 antibody, mBest4 antibody, bestrophin-3 antibody, bestrophin 3 antibody, Bestrophin 3 antibody, BEST3 antibody, Best3 antibody, best3 antibody

Background: BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD, MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738], Tsunenari et al., 2003 [PubMed 12907679]).

Molecular Weight: 50.8 kDa

Gene ID: 144453

NCBI Accession: NM_152439

HGNC: 144453