FXR2 antibody

Catalog No. ABIN272201

Product Details anti-FXR2 Antibody

Target: FXR2 (Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FXR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of FXR2 protein. (region surrounding Glu576)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity-Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FXR2

Target: FXR2 (Fragile X Mental Retardation, Autosomal Homolog 2 (FXR2))

Alternative Name: FXR2 (FXR2 Products)

Synonyms: id:ibd5046 antibody, zgc:56215 antibody, zgc:77472 antibody, FMR1L2 antibody, FXR2P antibody, Fxr2h antibody, FMR1 autosomal homolog 2 antibody, fragile X mental retardation, autosomal homolog 2 antibody, FXR2 antibody, fxr2 antibody, Fxr2 antibody

Background: Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene, and in the fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 can also interact with two fragile X syndrome related factors, FXR1 and FXR2, and these proteins form heterodimers through their N-terminal coilcoiled domains. FMR1 localizes to both the nucleus and the cytoplasm, and since it contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleo-cytoplasmic transport of mRNAs.Synonyms: FMR1L2, Fragile X mental retardation syndrome-related protein 2

Molecular Weight: approx. 65 kDa

Gene ID: 9513

NCBI Accession: NP_004851

UniProt: P51116