PSMB7 antibody (AA 58-277)

Catalog No. ABIN2729938

Product Details anti-PSMB7 Antibody

Target: PSMB7 (Proteasome (Prosome, Macropain) Subunit, beta Type, 7 (PSMB7))

Binding Specificity: AA 58-277

Reactivity: Human, Mouse, Rat, Monkey, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This PSMB7 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Characteristics: Homo sapiens proteasome (prosome, macropain) subunit, beta type, 7 (PSMB7)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Human recombinant protein fragment corresponding to amino acids 58-277 of human PSMB7(NP_002790) produced in E.coli.

Clone: 4G9

Isotype: IgG1

Application Details

Application Notes: WB 1:1000~2000, IF 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for PSMB7

Target: PSMB7 (Proteasome (Prosome, Macropain) Subunit, beta Type, 7 (PSMB7))

Alternative Name: PSMB7 (PSMB7 Products)

Synonyms: DDBDRAFT_0185624 antibody, DDBDRAFT_0232933 antibody, DDB_0185624 antibody, DDB_0232933 antibody, AU020723 antibody, MC14 antibody, Z antibody, 20S proteasome subunit beta-7 antibody, proteasome (prosome, macropain) subunit, beta type, 7 S homeolog antibody, proteasome subunit beta 7 antibody, proteasome (prosome, macropain) subunit, beta type, 7 antibody, proteasome (prosome, macropain) subunit, beta type 7 antibody, psmB7 antibody, psmb7.S antibody, PSMB7 antibody, Psmb7 antibody

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).

Molecular Weight: 29.8 kDa

Gene ID: 5695

NCBI Accession: NM_002799

HGNC: 5695

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA