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Melanoma antibody

Reactivity: Human IHC (p), IHC Host: Mouse Monoclonal 4A4 unconjugated
Catalog No. ABIN2742841
  • Target See all Melanoma products
    Melanoma
    Reactivity
    • 6
    • 2
    • 2
    • 2
    Human
    Host
    • 6
    Mouse
    Clonality
    • 6
    Monoclonal
    Conjugate
    • 6
    This Melanoma antibody is un-conjugated
    Application
    • 5
    • 5
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC)
    Specificity
    The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. has been shown to label the majority of melanomas. The MART-1/Melan A recognizes a protein of 18  kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45 and the MART-1 (cocktail) and Tyrosinase make this quadruple antibody cocktail a first-order pan melanoma screener.
    Immunogen
    Pigmented melanoma metastases from lymph nodes(HMB45). Recombinant human MART-1 protein(MART1). Recombinant tyrosinase protein (Tyrosinase).
    Clone
    4A4
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Target Species of Antibody: Human

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Buffer contains: 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    Melanoma
    Abstract
    Melanoma Products
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