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MSH6 antibody

MSH6 Reactivity: Human, Mouse, Rat, Dog WB, IP Host: Mouse Monoclonal 44 unconjugated
Catalog No. ABIN2743038
  • Target See all MSH6 Antibodies
    MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
    Reactivity
    • 78
    • 35
    • 29
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog
    Host
    • 58
    • 17
    • 3
    Mouse
    Clonality
    • 46
    • 32
    Monoclonal
    Conjugate
    • 46
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MSH6 antibody is un-conjugated
    Application
    • 53
    • 27
    • 25
    • 20
    • 14
    • 13
    • 12
    • 8
    • 8
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Specificity
    MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. cross reacts with mouse, rat and dog.
    Purification
    Purified
    Immunogen
    Synthetic human MSH6 peptide.

    Type of Immunogen: Synthetic peptide
    Clone
    44
    Isotype
    IgG1
    Top Product
    Discover our top product MSH6 Primary Antibody
  • Application Notes
    Approved: IP, WB (1:100 - 1:500)
    Comment

    Target Species of Antibody: Human

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Buffer contains: 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
    Alternative Name
    MSH6 (MSH6 Products)
    Synonyms
    GTBP antibody, GTMBP antibody, HNPCC5 antibody, HSAP antibody, p160 antibody, cb326 antibody, wu:fb36c12 antibody, LOC100227810 antibody, AU044881 antibody, AW550279 antibody, Gtmbp antibody, mutS homolog 6 antibody, mutS homolog 6 (E. coli) antibody, DNA mismatch repair protein antibody, MSH6 antibody, msh6 antibody, Msh6 antibody
    Background
    Name/Gene ID: MSH6

    Synonyms: MSH6, GTBP, HSAP, GTMBP, MutS (E. coli) homolog 6, HMSH6, Sperm-associated protein, p160, G/T mismatch-binding protein, HNPCC5, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit
    Gene ID
    2956
    Pathways
    DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
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