TCEB2 antibody (AA 1-118)

Catalog No. ABIN2754942

Product Details anti-TCEB2 Antibody

Target: TCEB2 (Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2))

Binding Specificity: AA 1-118

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCEB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Elongin-B protein (1-118AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TCEB2

Target: TCEB2 (Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2))

Alternative Name: ELOB (TCEB2 Products)

Synonyms: 0610040H15Rik antibody, cb162 antibody, wu:fb47e08 antibody, ELOB antibody, SIII antibody, elongin B antibody, Elob antibody, elob antibody, ELOB antibody

Background:

Background: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Aliases: EloB antibody, ELOB_HUMAN antibody, Elongin 18 kDa subunit antibody, Elongin B antibody, Elongin-B antibody, RNA polymerase II transcription factor SIII p18 subunit antibody, RNA polymerase II transcription factor SIII subunit B antibody, SIII antibody, SIII p18 antibody, TCEB 2 antibody, Tceb2 antibody, Transcription elongation factor B (SIII) polypeptide 2 antibody, Transcription elongation factor B polypeptide 2 antibody

UniProt: Q15370

Pathways: SARS-CoV-2 Protein Interactome