PLA2R1 antibody (AA 395-530)

Catalog No. ABIN2754969

Product Details anti-PLA2R1 Antibody

Target: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Binding Specificity: AA 395-530

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLA2R1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Secretory phospholipase A2 receptor protein (395-530AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PLA2R1

Target: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Alternative Name: PLA2R1 (PLA2R1 Products)

Synonyms: Pla2-r antibody, Pla2g1br antibody, Pla2r antibody, CLEC13C antibody, PLA2-R antibody, PLA2G1R antibody, PLA2IR antibody, PLA2R antibody, phospholipase A2 receptor 1 antibody, PLA2R1 antibody, Pla2r1 antibody

Background:

Background: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Aliases: 180 kDa secretory phospholipase A2 receptor antibody, C-type lectin domain family 13 member C antibody, CLEC13C antibody, M type receptor antibody, M-type receptor antibody, Phospholipase A2 receptor 1 antibody, PLA2 R antibody, PLA2-R antibody, PLA2G1R antibody, PLA2IR antibody, PLA2R antibody, PLA2R_HUMAN antibody, PLA2R1 antibody, Soluble PLA2-R antibody, Soluble PLA2R antibody, Soluble secretory phospholipase A2 receptor antibody

UniProt: Q13018

Pathways: Positive Regulation of Response to DNA Damage Stimulus